Follow Pennsylvania Avenue (Maryland Route 4) southeast from the Capitol Beltway for about 60 miles. At Solomons Island, continue across large bridge over the Patuxent River, to traffic light at intersection of Rte. 4 & Rte. 235. To avoid congestion at Lexington Park, continue on Route 4 for 8.5 miles until it ends at the intersection of Route 5. Turn left onto Rte. 5 and travel south about 14 miles. You will see a sign welcoming you to St. Mary's City then the St. Mary's River on the right as you enter the St. Mary's College of Maryland campus.
Look for Rosecroft Road on the right. Take Rosecroft Road, and then take first right (Hogaboom Lane) to the Visitor Center.